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Many people taking GLP-1 medications also use dietary supplements to enhance weight loss or support metabolic health

J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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This is why you can experience both mild and severe side effects