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Researchers opting for the 8mg maintenance dose would reach it at week 16, and the 4mg dose after just 4 weeks on the escalation schedule

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Lagou V., Jiang L., Ulrich A., Zudina L., Gonzlez K.S.G., Balkhiyarova Z., Faggian A., Chen S., Todorov P., Sharapov S
This balancing act was attempted by Novo Nordisk, when they developed a triple agonist , compound 16, which in mice was able to reduce body weight by an average of around 30%, fat mass by around 55% and lean mass by around 10% after 27 days [33]