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"Patients may not realize the risks associated with losing lean mass
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On one hand, GLP-1 receptor agonists delivered strong A1C reduction, meaningful weight loss, and cardiovascular benefit
We delineated neuronal and glial mechanisms of insulin resistance and glucagon-like 1 peptide (GLP-1) receptor agonism in human iPSC models of synucleinopathy, and corroborated our findings in patient samples from a Phase 2 trial of a GLP-1R agonist in Parkinsons (NCT01971242)
