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Questions to Ask Your Doctor or Practitioner Working closely with a healthcare provider can help you make the most of your GLP-1 journey

In a prespecified pooled analysis, semaglutide was superior to placebo in improving heart failure-related symptoms and physical limitations, enhancing exercise tolerance, and promoting significant weight loss, underscoring its potential to address both metabolic and functional deficits in obesity-related HFpEF [49]

The overall heterogeneity levels were 24.4% (95% uncertainty intervals, 0 and 54.9%) for nonfatal MI (moderate), 11.1% (95% uncertainty intervals, 0 and 48.0%) for nonfatal stroke (low) and 15.8% (95% uncertainty intervals, 0 and 49.9%) for CV death (moderate) (Additional file 1: Table S3)

For people who need clinically proven interventions for obesity or metabolic disease, prescription medications remain the gold standard with the strongest evidence base