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Committee recommendations influence but do not bind Health Canadas final decision

Therefore, given the rarity of suicidal or self-harming behaviors, the limited sample size of the RCT, and the inherent limitations of retrospective studies, comprehensive research with long-term follow-up and rigorous mental health assessments is needed to clarify the potential risks and benefits

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Trials have studied retatrutide in adults with obesity (BMI 30) or overweight (BMI 27) with comorbidities