what do glp-1 drugs do The Benefits of OutWeigh the Negatives? If GLP-1 Drugs Are Good
Description
Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo
2016;310:R885-95
Nielsen O
Early trials, concerned about possible cardiac safety issues, were designed to ensure that GLP-1 use did not negatively impact cardiovascular outcomes
