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18 Although treatments are available for diabetes and obesity, there are multiple long-term complications: they remain the leading causes of cardiovascular disease, eye pathology, lower limb amputation and end-stage renal disease

If you are prone to sleep disturbances on GLP-1 therapy , evening injection might worsen the problem rather than solve it

[1] [2] Other serious risks include pancreatitis, gallbladder disease, acute kidney injury, and diabetic retinopathy complications