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2 The American Diabetes Association 2016 guideline details a number of second-line options for use following MET and does not give preference to one drug class over the other
A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
Within the CNS, hindbrain GLP1 neurons project to numerous brain regions relevant to metabolic regulation in mice (Figure 1) (Burcelin et al., 2009
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