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GLP-1 receptor agonists are used for type 2 diabetes and weight loss, and mimic the way the naturally occurring hormone, GLP-1, acts in the body
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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems
