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These patients receive a signal which tells them not only to eat more, but also to store more of what they eat. When semaglutide binds to the brains GLP-1 receptors, it blocks the AGRP pathway and stimulates the POMC pathway

However, certain foods can stimulate your body to produce more GLP-1 naturally

She hopes to eventually transition off of it and maintain her weight through healthy habits, knowing it may be an ongoing challenge

A 2026 study published in The Lancet Obstetrics, Gynaecology & Womens Health found that combining GLP-1 therapy with HRT produced greater mean weight loss than GLP-1 alone in this patient population
