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In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

Abdalla MA, et al

Although GLP-1RAs are well established for treating obesity, type 2 diabetes, and for reducing cardiovascular risk, their potential role in inflammatory diseases such as RA has not been clearly defined

Triple combination therapy may be optimal for CV protection in type 2 diabetes Triple therapy combining an SGLT2 inhibitor, a GLP-1 receptor agonist and the thiazolidinedione pioglitazone could serve as an optimal solution for cardiovascular and renal protection in type 2 diabetes, according to a speaker