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However, altering a prescribed dosing schedule without medical supervision may increase risks and reduce effectiveness

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In the context of approved clinical trials, reconstitution and preparation of investigational medicinal products such as retatrutide is performed exclusively by trained pharmacy staff or clinical trial personnel, working under validated standard operating procedures and in accordance with MHRA Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP) requirements, as well as Royal Pharmaceutical Society standards for aseptic preparation

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