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That said, the pill still offers meaningful weight loss for many patients

Yes, both Wegovy and Zepbound, as GLP-1 medications, have shown significant effectiveness in reducing both food cravings and the urge to eat emotionally

GLP-1 antagonists block GLP-1 receptors, preventing the hormone from triggering these effects

Interestingly, it has been shown that rats consuming a 3 g meal displayed significant elevations in plasma GLP-1 within 56 min only in the hepatoportal vein and not in the vena cava [78], suggesting that, under physiological conditions, GLP-1R within the CNS is only reached by brain-derived GLP-1, since GLP-1 is also expressed by a discrete population of caudal brainstem neurons localized to neurons within the caudal (visceral) nucleus of the solitary tract (cNST) and adjacent medullary reticular formation in rodents and primates, including humans [83,84,85,86]