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Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]

PS, Primary suspect drug

Lajthia E, Bucheit JD, Nadpara PA, Dixon DL, Caldas LM, Murchie M, et al

This matters for BMI discussions because people starting at lower BMIs may reach a normal weight range faster on tirzepatide, which raises questions about treatment duration that our guide on GLP-1 treatment duration addresses in detail