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In the GLP-1 RA cohort, the risk of DKA remained broadly constant, whilst the risk of DKA within the SGLT2i cohort increased with time and the difference in risk became statistically significant at year 5

These mechanisms also variably produce hyperphagia, stemming from disturbed meal termination, decreased satiety, and increased food reward and craving, culminating in increased energy intake [2831]

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