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And the reason comes down to one receptor that neither semaglutide nor tirzepatide activates: the glucagon receptor

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To gain approval, one has to develop good documentation, he explains

A meta-analysis of GLP-1RA CVOT showed that treatment with GLP-1RA reduced the risk of developing a composite kidney outcome including new-onset MA by 21% compared to placebo (HR 0.79, 95% CI 0.73-0.87), with only ELIXA and EXSCEL not achieving significant benefit [11]
