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Despite the role of IELs in mediating intestinal mucosal repair through Fgf7/KGF ( Glp1r+ IELs into Glp1r / mice via bone marrow transplant does not rescue the intestinotrophic effects of exendin-4 in these mice (Koehler et al., 2015)
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The reduction in LFC was about 4.7% greater with tirzepatide than with insulin degludec
Folks who optimize this are able to toggle between fat and carbs as fuel, which promotes stable energy and reduced appetite
