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Hypertension is a significant risk factor for premature death

Here, we evaluate and review the function of SGLT2, SGLT2 inhibitors, their role in blood pressure control, the future of SGLT2 inhibitors as antihypertensive agents, and the possible mechanisms of SGLT2 blood pressure control in the central nervous system.

In experimental models, researchers often measure oxygen consumption, substrate oxidation patterns, metabolic biomarkers, and energy balance parameters to evaluate how receptor activation influences energy utilization across tissues