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doi: 10.1038/nrgastro.2013.105
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Recently, we reported that hyperleptinemia is indeed a driving force for diet-induced obesity, as the isolated intervention involving just an increase in circulating leptin levels, either by a transgenic approach using an adipocyte-specific leptin transgene or by frequent administration of exogenous leptin, are sufficient to promote weight gain in diet-induced obese mice (1416)
