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Highlights Small pilot studies show GLP-1RAs like liraglutide reduce binge eating, body weight, and comorbidities in binge eating disorder and bulimia nervosa

Additionally, GLP-1 RAs exhibit neuroprotective and anti-inflammatory effects, increase Akt dephosphorylation, decrease proinflammatory factors such as TNF-, elevate neurotrophic factors like BDNF, reduce oxidative stress and microglial activation, and enhance gut-brain axis function and gut microbiota stability [176]

However, it is estimated that 27% of the states adult population suffers from obesity an indication of the significant growth potential for enrollees prescribed a GLP-1 for weight loss

Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables