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Additionally, rapid weight loss itself is associated with adaptive thermogenesis , a physiological response where the body conserves energy by reducing heat production

In the analysis that follows, we categorize the main injectable weight loss drug candidates into three dosing-cycle intervals (as shown in the above chart)

Available from: Accessed: 19 Sep 2025 Frias JP, Hsia S, Eyde S et al (2023) Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study
