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The finding that tirzepatide binds 3-adrenoceptors with high in silico affinity modulating cAMP/cGMP balance and GLUT4 translocation in cardiomyocytes independently of canonical incretin receptor engagement (Aydos et al., 2025) illustrates that the full mechanism of action of an already-approved drug remains incompletely characterized

[DOI] [PMC free article] [PubMed] [Google Scholar] Edwards CMB, Todd JF, Mahmoudi M, Wang Z, Wang RM, Ghatei MA, et al

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These legal actions allege that pharmaceutical companies like Novo Nordisk and Eli Lilly should have included more explicit warnings regarding the risks associated with their diabetes drugs