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Individual results will vary based on factors including age, baseline weight, metabolic health, consistency of use, lifestyle factors, genetic factors, current medications, and other individual variables

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Differences in cancer outcome definitions across trials were addressed by grouping clinically equivalent endpoints (e.g., hepatocellular carcinoma and primary liver cancer) and accounting for heterogeneity through random-effects modeling, sensitivity analyses, and GRADE downgrading for indirectness where appropriate