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In summary, convergent evidence from both preclinical and clinical research underscores the capacity of GLP-1RAs to interact with neural circuits that govern reinforcement and motivation, networks that are also targeted by drugs of abuse

headache was the most common side effect, and exploratory breast-milk measures suggested rapid clearance Pre-registered experiment gave 78 healthy volunteers inert air framed as nitrous oxide Context alone increased altered states, ego dissolution, dissociation, and side effects, despite no active drug Suggestibility and absorption helped predict who was most responsive, sharpening how we think about set, setting, placebo, and nocebo effects - Two randomised trials tested oral prolonged-release ketamine: a Phase 1 crossover study (n=26) and a Phase 2 placebo-controlled TRD trial (n=122) The tablet caused far less dissociation and cardiovascular change than intranasal esketamine But it missed the main day-21 depression endpoint, showing that better tolerability does not automatically mean better efficacy ;: June brought a striking early GH001 signal in postpartum depression, a reminder that context can produce psychedelic-like effects without a drug, and a ketamine formulation trial where better tolerability did not translate into a clear antidepressant win

doi: 10.1080/14787210.2021.1964955 39