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Description
Despite the digestive challenges inherent to swallowing a peptide medication, oral semaglutide achieves bioavailability comparable to injections when taken on an empty stomach following specific instructions

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This occurs through directly stimulating POMC/CART neurons and indirectly inhibiting neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons, which can lead to reduced energy intake [3]

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