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Description
AP events were predominantly reported for unknown indications (53.8%) and T2DM (43.0%)
They are also very expensive, which presents a challenge for plan sponsors
Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system
Governments and pharmaceutical companies should work together to address these issues
