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Description

semaglutide 0.5 mg (n=12), 1.0 mg (n=12), or placebo (n=12)

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Compounded meds aren't FDA-approved.

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Retatrutide, a triple-hormone injection, produced up to 30.3% average weight loss in the phase 3 TRIUMPH-1 trial

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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

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