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Meanwhile, orforglipron demonstrated significant weight loss efficacy [8] consistent with injectable GLP-1 medicines

Advice on treatment or care of an individual patient should be obtained through consultation with a trained health care practitioner

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines.3 That study didnt report why 50% of diabetics on GLP-1 RAs discontinued them, but gastrointestinal (GI) adverse events were a suggested cause.3 Adverse events are just one of a number of reasons that people stop using these drugs, as follows.

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