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Description
They are first released into the stomach acid where they help produce specific metabolites, and short chain fatty acids acetate, propionate, and butyrate
A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)
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Furthermore, GLP-1 has the ability to decrease gastric acid secretion and postprandial gastric emptying, limit gastric and duodenal peristalsis through vagus nerve inhibition, and raise pylorus pressure, all of which contribute to a decrease in appetite, weight loss, and the so-called "ileal braking" effect [121]
