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With 2024 as the year when the AOM market took shape, and 2026 a pivotal year that will define future competitive dynamics as the next wave of AOMs launch, and when the first off patent semaglutide likely becomes available in some countries, it is easy to dismiss 2025 as an uneventful transition

Sequence modification to enhance DPP-4 resistance combined with covalent attachment of a fatty acid leads to slower absorption and mediates albumin binding in plasma, a strategy employed in the development of the once-daily and once-weekly agents, Victoza and Ozempic, respectively

Meier 2012)

The first six amino acids at the N-terminus of GLP-1, are further truncated by post-translational processing in the intestinal cells resulting in forming ~31 amino acid peptides - GLP-1(7-37) or GLP-1-(7-36) as shown in Figure 4 below
