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Medical Conditions or Medications Certain conditionslike thyroid disorders, insulin resistance, or medications that promote weight gaincan blunt the effects of GLP-1s

The evidence reviewed establishes GLP-1 RAs as transformative precision medicine tools that exemplify how mechanistic understanding can drive therapeutic innovation in addressing complex, interconnected diseases through targeted modulation of biological pathways

GLP-1 medications are not safe for everyone

21NSFCP37) awarded to BX and National Natural Science Foundation of China grants (Grant Nos.82201653) awarded to RL, which provided direct funding for the experiments reported in this manuscript