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Retrieved from Hale, P.M

Our research study faced limitations primarily due to the high heterogeneity among included studies and the relatively low number of articles in our meta-analysis

Direct nutrient stimulation may induce the initial release of GLP-1 from small intestinal EECs, while large intestinal EECs likely release GLP-1 via a neural hormonal reflex or from microbe-derived metabolites, although this remains to be explored 93,99 (see the Gut microbiotabrain connection section)

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