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Implications for employers : Employers should expect coverage of GLP-1 drugs for obesity to improve population health and employee productivity, but the return on investment from coverage is not likely to lead to lower medical costs now or in the future

The development of GLP-1 receptor agonists for type 2 diabetes was contextualised within the broader research landscape, including orally bioavailable agonists, allosteric modulators, and unimolecular multi-agonists all of which use the native GLP-1 receptor as their primary target

A comparison of GLP-1R structures with ligand removed (and ECD removed in top views) for clarity

Its a one-two punch that promises to make us leaner, stronger and fitter than we ever dreamed possible