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For size fractionation studies, bacterial cell-free supernatants were separated by size using centrifugal filter units (Amicon)

The apparent contradiction between these potential protective mechanisms and clinical observations of retinopathy worsening likely reflects the complex interplay between rapid metabolic changes and pre-existing vascular damage

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Similar response in control group: Both interventions produced comparable lipid-lowering effects in hypercholesterolemic participants, making it difficult to isolate the true impact of yerba mate
