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This can lead to reduced expression of GLP- 1 receptors and the development of GLP- 1 resistance

These three drugs were approved based on cardiovascular safety data from their development programmes, and each was later followed by a dedicated CVOT: exenatide with EXSCEL, 5 albiglutide with Harmony Outcomes 6 and dulaglutide with REWIND

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Global overview: Drug demand, drug supply
