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The bupropion component carries an FDA boxed warning for increased suicidal ideation in young adults, similar to other antidepressants

The Institute for Health Metrics and Evaluation (IHME) estimates that high body mass index accounts for more than 160 million disability-adjusted life years globally, while diabetes prevalence continues to rise steadily, reinforcing demand for effective therapies like GLP-1 receptor agonists

Gastroenterology 113 , 6066 (1997)

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