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That third target is the same one tirzepatide uses, and its generally believed to improve tolerability of the GLP-1 effect while contributing its own metabolic benefit
In studies with rodents, tirzepatide caused thyroid tumors, including thyroid cancer

Januvia is a DPP-4 inhibitor which works by increasing the levels of incretin hormones like GLP-1 that help to regulate insulin production after meals, reducing blood sugar spikes

FAQs Does semaglutide cause thyroid cancer
