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Chronic hypercortisolismwhether from endogenous Cushing's syndrome or exogenous glucocorticoid therapyproduces a characteristic metabolic phenotype

Am J Physiol Gastrointest Liver Physiol 2010;298:G364-G374

The analysis covers two questions: is there prior art sufficient to support a credible petition, and is the patents claim scope and written description defensible against the specific grounds most likely to be raised

This requires a comprehensive assessment of the patients clinical characteristics, such as the duration of diabetes, presence of comorbidities, body mass index, and response to previous treatments