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Some individuals report that hunger feels more intense initially, though this likely represents return to baseline rather than true rebound hyperphagia

About one-third of participants achieved 20% or greater weight loss, while some achieved less than 10%
This is where things get complicated, and where having a larger vial supply simplifies logistics

This model has already transformed T2D care, where antihyperglycemic therapies are selected not only for their glucose-lowering efficacy but for their ability to reduce cardiovascular events, preserve renal function, and improve hepatic or heart failure outcomes