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As a result, it is difficult to delineate the exact mechanism, he says

Goodman & Gilmans The Pharmacological Basis of Therapeutics

10.1056/nejmoa2403664

Studies emphasized Th2 cytokines as the primary stimuli for the atopy of AD 19 , and that ACD is a type IV cutaneous cell-mediated hypersensitivity reaction triggered by environmental allergens 20 , whereas urticaria is an IgE-mediated allergic dermatologic disease 21
