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In a double-blind, randomized, placebo-controlled clinical trial involving 62 adults with PWS, topiramate therapy was well tolerated and exerted a beneficial effect on eating behaviors in a dose-dependent manner, although no significant reduction in BMI was observed [49]

Others may argue that for people who have a large percentage of weight to lose and struggle getting started with a more foundational approach to weight loss, drugs like Wegovy can give them a jump start or help get their foot in the door on healthier habits by helping them control their appetite in the beginning
