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& Schleicher, E

In all SURPASS programs, tirzepatide demonstrated a much greater HbA1c-lowering impact than placebo or active comparators, such as basal insulin and GLP1RAs [83, 86]

These symptoms usually improve as your body adjusts

The FDA-approved prescribing information for both semaglutide and tirzepatide specifically notes that they delay gastric emptying, which contributes to reduced appetite and caloric intake