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While most insurance companies will cover the cost of this medication when it's used to treat type 2 diabetes, it usually isn't covered when used off-label for weight loss

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The gastrointestinal side effects of GLP-1 agentsparticularly vomiting and diarrheacan lead to depletion of essential electrolytes including sodium, magnesium, potassium, and calcium, all of which are critical for normal muscle contraction and relaxation

Baseline characteristics, from Lambourg et al , Am J Kidney Dis, 2025 Table 2 shows that before weighting, patients who continued metformin differed from those who stopped it