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Proper site rotation becomes particularly important with daily injections to prevent localized tissue changes
Coskun T, The Lancet (Vol 402, Issue 10401, Aug 12, 2023, pp 529544)
The 12mg group lost approximately 17.5% by week 24 (month 6)
When prescribed in the usual oral dosage range of 250 to ~2550 mg/day for the treatment of T2DM and in the absence of reduced renal function, it is unlikely that peak plasma levels of metformin would exceed 15-20 M, with trough levels of between 1-5 M, and a plasma half-life of approximately 3 to 5 hours
