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Many physicians use a microdosing protocol as an offramp slowly tapering down to allow natural metabolism to adapt

Results show a weight loss of more than 6% Trusted Source PubMed Central Go to source , but no effect on IBD disease activity

When calorie intake drops and body weight declines quickly, bone turnover may accelerate

Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment