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The TESTING randomized controlled clinical trial consisted of 503 patients randomized with 257 in the treatment group and 246 in the placebo group

And retatrutide vs tirzepatide comparisons suggest retatrutide edges ahead by 3 to 5 percentage points at comparable dose levels

The key mechanistic distinction is GIPR engagement: retatrutide adds GIP receptor agonism to the GLP-1R/GCGR dual mechanism, which published investigational data associate with enhanced adipose signalling and weight loss outcomes

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