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As a result of the lack of available safety data, some of the GLP-1 acting drugs are not advised for use during pregnancy

While effective, its weight loss results are generally more modest than those seen with injectable versions of the same active ingredient

Two unique compounds have been evaluated in Phase 2 trials (SAR425899 and MEDI0382), and although dual-agonism has produced promising results on body weight and glycemic control in diabetic patients [926,927], it is not apparent that these co-agonists are superior to selective GLP-1R agonists

BRET assays and in vitro quantification of PPAR-responsive genes were performed as described in Supplementary Information 1