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These effects are observed across substances and models, including operant self-administration, CPP, reinstatement paradigms, and neurochemical readouts

If youre having side effects, your dose is too high, Eliszewski says

For a broader look at the treatment class, see how GLP-1 actually works for weight loss

Regardless of cause, sustainability of outcomes remains unclear because adherence to treatment, as with many other drugs, may be an issue