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These data suggested that the gut makes a hormone(s) that regulates insulin levels, and they came to be known as incretins which were defined by Creutzfeld as factors that i) are released from gut in response to carbohydrates, ii) stimulate insulin secretion, and iii) act only in the presence of high blood glucose (2)
Research published in The Lancet examining GLP-1 receptor agonist eligibility across 99 countries found that eligibility varies dramatically based on which BMI thresholds are used

This makes extended therapy financially predictable for those pursuing sustained weight management success

Interestingly, improvements in anxiety-like behavior after loss of GLP-1R were only noted in females, potentially suggesting females rely more on this system to maintain a baseline of normal anxiety-like behavior (113)