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Two studies161,162 examined the acute effects of exenatide on intravenous cocaine self-administration, which is considered the gold standard for assessing the effects of injected drugs including cocaine

55 pM for GLP-1 in one cellular assay (99)

After absorption, the pharmacokinetic properties and effects of semaglutide are similar, irrespective of the route of administration (103)

Initially, they had planned to continue the study for a further year, but because of the lack of positive results, they cancelled the extension